Research on the
RNase-L dysfunction biomarker

as conducted by Prof. Robert Suhadolnik, Ph.D., et al.

Updated:    1997


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Brief Summary

MARKER STUDY IS PUBLISHED: A study was published on Thursday, July 17, 1997 which identifies a possible biological marker for CFS. This work was first described by lead researcher Robert Suhadolnik at last October's AACFS conference in San Francisco. The study shows a unique enzyme present in CFS patients that does not appear in healthy controls. Also, two studies in Europe have confirmed this study and will be published later this year, according to remarks made by Suhadolnik at a Congressional briefing given on May 16 in Washington, DC. The current paper was published as:

Suhadolnik RJ, Peterson DL, O'Brien K, Cheney PR, Herst CVT, Reichenbach NL, Ning K, Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P, Charubala R, Pfleiderer W.
Biochemical Evidence for a Novel Low Molecular Weight 2-5A-Dependent RNase L in Chronic Fatigue Syndrome. Journal of Interferon and Cytokine Research, July 1997, 17:377-385.
Robert Suhadolnik, Ph.D., is a professor of biochemistry at Temple University School of Medicine in Philadelphia and is a member of the university's Fels Institute for Cancer Research and Molecular Biology. His laboratory has been involved in studies of virus-associated diseases and cancers for the past 15 years and has been awarded research grants by the National Institutes of Health to study CFS, and AIDS.

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